Like the 7th Middle School, the 16th Middle School is inclusive, open, and diverse, rather than meritoclastic. And because it is located in the old town of Guangzhou, the localized atmosphere of the 16th Middle School is very strong, and it is very "Guangzhou". Compared with schools with militarized management such as Tie I, No. 16 Middle School can make students feel more free. Founded in 1934, the 16th Middle School was formerly known as Guangzhou Peigui Middle School, and the first principal was Mr. Ma Junwu, a famous educator and democratic revolution activist in modern times, who was praised by Zhou Enlai as "a generation of grandmasters". In 1953, the No. 16 Middle School was changed to a public school, and in 1994, it was rated as the first batch of first-class schools in Guangdong Province.

In the 2017 high school entrance examination, the 16th middle school did not announce the specific results as always, among which the content of the good news report was "all indicators have reached the predetermined goals, the proportion of more than 700 points has reached a new high, and the number of people with high scores and high sections of a single subject ranks among the top middle schools in the district". However, combined with the results of the college entrance examination of the 16th Middle School and the reputation among the parent group, its overall school-running strength ranks above average.

The openness and diversity of the 16th Middle School can be seen in its teaching methods. When most schools adopt the tactics of sea of questions to prepare for the high school entrance examination, the 16th middle school does not follow the trend, but stipulates that "all teaching should not occupy students' lunch breaks and self-study classes", and at the same time, through strict after-school homework regulations and student forums, to avoid too much homework. It is understood that the reason why the 16th Middle School abandoned the heavy homework is to avoid "fatigue combat", and the school emphasizes that teachers focus on the 40 minutes of the classroom and study how to improve the efficiency of the classroom. And how to improve the efficiency of the classroom? The 16th Middle School allows teachers to learn from each other's strengths through the method of "preparing lessons collectively at regular times and taking turns to teach".

If we only focus on teaching, of course, we will not reflect the diversity of the 16th Middle School. Every year, the school will have a school sports meeting, a science and technology cultural festival and a spring outing, as well as cultural and sports activities such as the Top Singer singing competition, whether it is planning, holding or participating in competitions, students can get full exercise. The number of clubs in the 16th Middle School is also very large, and the old clubs include the Literature Club, the Dance Club, the Music Club, the Animation Club, the Taekwondo Club, and the new Magic Club, Model Club, Finance Club, Model United Nations, Photography Club, etc., campus life is not boring.

The first year students of No. 16 Middle School are all arranged in the South Campus (formerly No. 79 Middle School), which is located on Dashatou Fourth Road, Yuexiu District. The campus has a teaching building, a laboratory building, a comprehensive building, a student apartment and a canteen, a 200-meter track sports field, and 14 lunch break rooms, which are equipped with lunch break beds for every day student. However, the student residence is only for high school students (junior students also study on the South Campus). The second and third junior high school students are studying at the Zhongshan 2nd Road Campus, which has relatively simple hardware facilities, with only basketball courts, volleyball courts, badminton courts, table tennis halls and a 200-meter circular track, no swimming pool and football field, and all students are day students. In addition, the 16th middle school has strict requirements for students' grooming, such as requiring boys and girls to cut their hair short and not wear jewelry.